DNA Methylation and Child Proof Outlet Covers

DNA Methylation and Child Proof Outlet Covers

DNA contains our genetic code for who we are. When we need new proteins, enzymes, and cells, specific areas of the DNA called genes are copied to produce these new products. When DNA is methylated (the addition of a carbon and three hydrogen molecules to the DNA), the ability for the gene to express or be copied is blocked. This prevents unwanted proteins and cells from being replicated. The methyl groups bind to areas on the DNA strand called CpG sites. CpG stands for Cytosine-phosphate-Guanine. The CpG site acts like a plug. If the CpG site is filled with a methyl group, the gene can’t replicate. If there is no methyl group attached to the CpG site the gene can be copied. I’ll use an analogy to make this easier to understand. When I want to use my vacuum cleaner I need to plug it into electricity. There are specific spots in my wall where I can plug the cord in called outlets. Our DNA is a long molecule. There are specific areas on the DNA where replication can occur. The CpG sites signify the areas where replication can occur. When a gene needs to replicate to produce new proteins, messengers molecules called “transcription factors” (the plug of my vacuum) are sent to the DNA to bind to the CpG sites (the outlet). When the two combine, the gene is able to be copied. When my kids were little, we put protective covers on our electrical outlets when we weren’t using them to prevent the kids from sticking things in the outlet and getting an unwanted shock. Methyl groups...
The Top 10 Functions of Methylation

The Top 10 Functions of Methylation

What is methylation and why does it matter?  Methylation is a metabolic process that happens in every cell of the human body and is critical to optimal function. Without methylation life doesn’t exist. Methylation is involved in nearly 200 reactions in the human body. The quality of those methylation reactions ultimately determines our level of health and function. So what is methylation? Methylation is the transfer of a chemical fragment called a methyl group (carbon atom linked to three hydrogen atoms) from one molecule to another. These methyl groups act like keys to turn on and off the 200+ methylation reactions in the body. A molecule that donates a methyl group is termed a methyl donor. The most abundant methyl donor in the body is a molecule called SAM (S-adenosylmethionine). Without adequate SAM production and the actual methylation reactions, our health and function can become mildly to severely compromised. So what does methylation actually do? Here are the top 10 functions of methylation: Gene regulation: Methylation is involved in turning off and on our genes. Methyl donors act like “keys” to turn off and on the expression of the genes. At the root of what causes cancer is hypo or hyper methylation (technically it is a combination of both). Biotransformation: The processing of chemicals within the human body is called biotransformation. Methylation is involved in the process of making and degrading chemicals within our bodies, as well processing as those we consume from our environment (xenobiotics). Production of neurotransmitters: Methylation is required to make neurotransmitters which are the chemicals our nerve cells use to communicate with each other. Without...
What Is Methylation?

What Is Methylation?

Methylation is the addition of a carbon and three hydrogen molecules to another molecule. These “methyl” groups act like keys or switches that turn on and off hundreds of different reactions within our bodies. Methylation reactions are critical to life and occur constantly and continuously within our bodies. Methylation reactions are involved in: The regulation of our genes The processing of chemical within our bodies Building neurotransmitters Metabolizing neurotransmitters Processing hormones Building immune cells DNA synthesis and repair Histone synthesis Energy production Myelin production Building and maintaining cell walls and membranes Production of glutathione the master antioxidant in the body Inflammation responses The state of your methylation processes determines the state of your health. The healthier and more functional your methylation processes are the healthier you are and the slower you degenerate and decay. Nearly every medication taken is to reduce or manage the symptoms of faulty methylation. So, what is methylation? Methylation is the vital metabolic reactions that occur billions of times per second in our body that allow us to be...
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